产品货号：
Z29770
中文名称：
XAF1抗体
英文名称：
Anti-XAF1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-XAF1 Antibody |
| 指标别名 | XAF1;BIRC4BP;XIAPAF1;BIRC4-binding protein |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | XAF1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human XAF1 recombinant protein (Position:Q197-S301). |
| 实际分子量 | 34KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | XAF1 also called XIAP-associated factor 1,antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells.By genomic sequence analysis,the XAF1 gene contains 7 exons spanning 18kb.Southern blot analysis suggested that XAF1 is a single-copy gene.The XAF1 gene is mapped on 17p13.1.Fluorescence microscopy demonstrated nuclear expression of XAF1,in contrast to the cytoplasmic expression of XIAP.Functional analysis indicated that XAF1 reverses the XIAP-mediated inhibition of CASP3 and its protection against apoptosis.Northern blot analysis detected wide expression of 3.9-,4.5-,6.0-,and 7.0-kb XAF1 transcripts,with highest levels in heart and ovary and lowest levels in brain and testis.Antisense experiments determined that loss of XAF1 expression enhances resistance to apoptosis.Alteration in XAF1 and XIAP RNA expression levels may lead to increased apoptotic resistance and proliferation due to unregulated XIAP function in cancer cells. |
| Uniprot ID | Q6GPH4 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P). |
| 基因名全称 | XIAP associated factor 1 |
| 蛋白名全称 | XIAP-associated factor 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 (ELISA)： 1:100～1000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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